BC Cancer Agency Scientists Uncover New Potential Treatment Options for Lymphoid Cancer


Photo Caption (L-R): Dr. Christian Steidl, Jay Gunawardana, PhD student and lead author

Dr. Christian Steidl, a scientist at the BC Cancer Agency, has published a paper in Nature Genetics, describing novel gene mutations that may lead to new and improved therapies for lymphoid cancer patients.

The mutations were found in two subtypes of lymphoid cancer known as mediastinal B cell lymphoma (PMBCL) and Hodgkin lymphoma (HL). Using high-throughput genomic sequencing, Dr. Steidl and his colleagues identified the entirety of genetic mutations in PMBCL tumours and discovered previously unknown mutations of the PTPN1 gene in 20-25% of patients with PMBCL and HL. This discovery will enable further research into the development of targeted treatments for lymphoma patients with PTPN1 mutations.

BC Cancer Agency-Discovered Protein May Hold the Key to Treating Huntington Disease



In 2013, the BC Cancer Agency's Dr. Poul Sorensen and his colleagues published a study explaining the role of HACE1, a protein discovered in their lab, in the development of Wilms' tumours, a pediatric cancer of the kidneys. The study proposed that by changing the activity or levels of HACE1 in tumour cells, it might be possible to block DNA-damaging oxygen molecules, resulting in better options for pediatric patients.

Just a few weeks ago, an international team of scientists, led by Dr. Sorensen's lab at the BC Cancer Agency in collaboration with colleagues from the Centre for Molecular Medicine and Therapeutics and the MRC Toxicology Unit in Leicester, UK, published a new paper explaining that the same HACE1 protein may also have implications for Huntington disease, a neurodegenerative disorder with no known cure.

Much like the protective role played by HACE1 in cancer, the protein may also be able to protect brain cells from degeneration. With this knowledge, scientists may be able to develop a treatment to stop or even reverse the progression of Huntington disease. Read more.

1st Annual Anita Cochrane Memorial Awards Bring Hope to Breast Cancer Patients in B.C.



Anita Cochrane was an inspiring young woman who, after being diagnosed with breast cancer, spent the final decade of her life raising awareness and participating in the BC Cancer Foundation's Weekend to End Breast Cancer in support of breast cancer research at the BC Cancer Agency.

Since Anita's passing in 2010, her family has continued to host an annual golf tournament, Saving the Girls, in her honour. The proceeds from this event, as well as interest from the Anita Cochrane Memorial Endowment Fund, support the Anita Cochrane Memorial Awards.

The first competition for the awards was held this year: applications were received from leading experts in breast cancer research at the BC Cancer Agency and reviewed by a committee. Five successful applicants will receive funding to support pilot studies in breast cancer research and education. Anita's legacy will ensure that new solutions for breast cancer are found and bring hope to future generations of women affected by breast cancer.

Six-year-old Violinist Honours his Grandfather with Music

When his grandfather Marvin was diagnosed with pancreatic cancer in February 2013, six-year-old Yosef Nider knew he had to do something to raise money and awareness for cancer research.

With an initial goal of $1,000, Yosef set out to host a violin concert to honour his grandfather and raise money for the BC Cancer Agency. The inspiring concert took place on February 26 at Yosef's school, raising an incredible $8,790.85!

Yosef is a champion and leader in his community and an example to British Columbians of all ages. The BC Cancer Foundation is very proud to call Yosef our partner in discovery.